The table below shows each target's Open Targets genetic association score with each age-related diseases/trait, as well as the multimorbidity count (total number of associated morbidities). Icons indicate any Hallmarks of Ageing that the target is involved in according to its GO annotations.
Select a target for more detailed information. Much more information about a target and its association with disease, including drug and clinical trial information, can be found via the link to its Open Targets Platform profile on the right.
Target information
Hallmarks Icons
GenAge & CellAge Icons
GenAge is an expert-curated database of age-related genes. The GenAge ID number links to the GenAge entry for relevant targets, and icons indicate whether animal model orthologs have experimental evidence of pro-longevity or anti-longevity effects.
CellAge is a manually-curated database of genes associated with cell senescence through genetic experiments in human cell types. The icons indicate whether the gene was found to induce or inhibit senescence.